The Gain Trial


GAIN Trial


Glasgow Memory Clinic are looking for volunteers who may be suitable to take part in our most recent study, the GAIN Trial.

The GAIN Trial is based on a growing body of scientific evidence that the bacteria P.gingivalis, most commonly associated with degenerative gum disease, can affect the brain and cause Alzheimer’s disease.

The Gain trial discovery

This clinical trial will evaluate whether the investigational oral drug COR388 is safe and can slow or halt the progression of Alzheimer’s disease by inactivating the toxic proteins, called gingipains, released by the bacteria and stop or slow further damage to healthy brain cells.

Alzheimer’s disease affects more than 30 million people worldwide and around 850,000 in the UK alone. Recent scientific discoveries have led to a new understanding of the cause of Alzheimer’s disease that could revolutionise the way that it is treated. Even if you have no symptoms of gum disease, you may still be at risk.


You or somebody you know may be eligible for the GAIN study if you:

  • Are 55 to 80 years old
  • Have been diagnosed with mild to moderate Alzheimer’s disease 
  • Have a caregiver or family member who can attend study visits with you, report on daily activities and oversee you taking medication


Please fill out our pre-screening survey below to check eligibility.